Osteopathic Research

Osteopathic Research
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The past decades have seen a significant increase in research on Osteopathic Manipulative Treatment (OMT). The body of research on OMT has now reached the point where Osteopathy has become an accepted part of the medical literature.

As with other common medical procedures (such as surgery, pain procedures or interventional cardiology and radiology), OMT study design has different challenges with blinding, sample size, controls, and the skill of the physician, when compared with pharmaceutical research. Osteopathic manipulation must be evaluated in comparison with  research on other procedures in medicine, and it compares favorably in terms of safety, efficacy, and overall study design.

The studies linked below cover the use of OMT for low back pain, the discomforts and complications of pregnancy and surgery, its use and safety with children and other topics. These build on the the work of earlier Osteopathic researchers such as Louisa Burns, Wilbur Cole, Irvin Korr, John Denslow, and Viola Frymann, to name a few.

Visit the Osteopathic Research Center located at the University of North Texas Health Science Center home of the Texas College of Osteopathic Medicine

Visit  OSTMED.DR which is a digital library of Osteopathic research from the past 100+ years

Research Articles - organized by topic
(last updated 01.29.20)


Lowback Pain

Back Pain is one of the most common conditions for which osteopathic treatment is used. These articles study its use in both acute and chronic settings.
(see also Obstetrics/Gynecology)

LBP Clinical Trials:

Martí-salvador M, Hidalgo-moreno L, Doménech-fernández J, Lisón JF, Arguisuelas MD. Osteopathic Manipulative Treatment Including Specific Diaphragm Techniques Improves Pain and Disability in Chronic Nonspecific Low Back Pain: A Randomized Trial. Arch Phys Med Rehabil. 2018;99(9):1720-1729. PMID: 29787734

Richter D, Karst M, Buhck H, Fink MG. Efficacy of Fascial Distortion Model Treatment for Acute, Nonspecific Low-Back Pain in Primary Care: A Prospective Controlled Trial. Altern Ther Health Med. 2017;23(5). PMID: 28646809

Licciardone JC, Gatchel RJ, Aryal S: Recovery from Chronic Low Back Pain after Osteopathic Manipulative Treatment A Randomized Controlled Trial. J Am Osteopath Assoc. March 2016 Vol 116, e144-155. DOI: 10.7556/jaoa.2016.031. PMID: 26927908

Licciardone JC, Gatchel RJ, Aryal S: Targeting Patient Subgroups With Chronic Low Back Pain for Osteopathic Manipulative Treatment: Responder Analyses From a Randomized Controlled Trial. J Am Osteopath Assoc. 2016 Mar;116(3):156-68. doi: 10.7556/jaoa.2016.032. PMID: 26927909

Licciardone JC1, Aryal S2: Clinical response and relapse in patients with chronic low back pain following osteopathic manual treatment: results from the OSTEOPATHIC Trial. Man Ther. 2014 Dec;19(6):541-8. doi: 10.1016/j.math.2014.05.012. Epub 2014 Jun 5. PMID: 24965494

Tamer S, Oz M, Ulger O: The effect of visceral osteopathic manual therapy applications on pain, quality of life and function in patients with chronic nonspecific low back pain. J Back Musculoskelet Rehabil. 2016 Nov 11. PMID: 27858681

Martins WR, Diniz LR, Blasczyk JC, Lagoa KF, Thomaz S, Rodrigues ME, de Oliveira RJ, Bonini-Rocha AC: Immediate changes in electroencephalography activity in individuals with nonspecific chronic low back pain after cranial osteopathic manipulative treatment: study protocol of a randomized, controlled crossover trial. BMC Complement Altern Med. 2015 Jul 13;15:223. doi: 10.1186/s12906-015-0732-2.
PMID: 26165865

Vieira-Pellenz F, Oliva-Pascual-Vaca A, Rodriguez-Blanco C, Heredia-Rizo AM, Ricard F, Almazán-Campos G: Short-term effect of spinal manipulation on pain perception, spinal mobility, and full height recovery in male subjects with degenerative disk disease: a randomized controlled trial. Arch Phys Med Rehabil. 2014 Sep;95(9):1613-9. doi: 10.1016/j.apmr.2014.05.002. Epub 2014 May 24. PMID: 24862763

Prinsen JK, Hensel KL, Snow RJ: OMT associated with reduced analgesic prescribing and fewer missed work days in patients with low back pain: an observational study. J Am Osteopath Assoc. 2014 Feb;114(2):90-8. doi: 10.7556/jaoa.2014.022. PMID: 24481801

Schwerla F, Kaiser AK, Gietz R, Kastner R: Osteopathic treatment of patients with long-term sequelae of whiplash injury: effect on neck pain disability and quality of life. J Altern Complement Med. 2013 Jun;19(6):543-9. doi: 10.1089/acm.2012.0354. Epub 2012 Dec 28. PMID: 23273259

Licciardone JC, Kearns CM, Minotti DE: Outcomes of osteopathic manual treatment for chronic low back pain according to baseline pain severity: Results from the OSTEOPATHIC Trial. Man Ther. 2013 Jun 8. doi:pii: S1356-689X(13)00084-2. 10.1016/j.math.2013.05.006. [Epub ahead of print] PMID: 23759340

Licciardone JC, Kearns CM, Hodge LM, Minotti DE. Osteopathic Manual Treatment in Patients With Diabetes Mellitus and Comorbid Chronic Low Back Pain: Subgroup Results From the OSTEOPATHIC Trial. J Am Osteopath Assoc. 2013 Jun;113(6):468-78. PMID: 23739758

Licciardone JC, Minotti DE, Gatchel RJ, Kearns CM, Singh KP: Osteopathic manual treatment and ultrasound therapy for chronic low back pain: a randomized controlled trial. Ann Fam Med. 2013 Mar;11(2):122-9. doi: 10.1370/afm.1468. PMID: 23508598

Licciardone JC, Gatchel RJ, Kearns CM, Minotti DE: Depression, somatization, and somatic dysfunction in patients with nonspecific chronic low back pain: results from the OSTEOPATHIC Trial. J Am Osteopath Assoc. 2012 Dec;112(12):783-91. PMID: 23212429

Licciardone JC, Kearns CM, Hodge LM, Bergamini MV: Associations of cytokine concentrations with key osteopathic lesions and clinical outcomes in patients with nonspecific chronic low back pain: results from the OSTEOPATHIC Trial. J Am Osteopath Assoc. 2012 Sep;112(9):596-605. PMID: 22984233

Licciardone JC, Kearns CM: Somatic dysfunction and its association with chronic low back pain, back-specific functioning, and general health: results from the OSTEOPATHIC Trial. J Am Osteopath Assoc. 2012 Jul;112(7):420-8. PMID: 22802542

Parker J, Heinking KP, Kappler RE: Efficacy of osteopathic manipulative treatment for low back pain in euhydrated and hypohydrated conditions: a randomized crossover trial. J Am Osteopath Assoc. 2012 May;112(5):276-84. PMID: 22582197

Cruser dA, Maurer D, Hensel K, Brown SK, White K, Stoll ST: A randomized, controlled trial of osteopathic manipulative treatment for acute low back pain in active duty military personnel. J Man Manip Ther. 2012 Feb;20(1):5-15. PMID: 23372389

Schwerla F, Bischoff A, Nurnberger A, Genter P, Guillaume JP, Resch KL: Osteopathic treatment of patients with chronic non-specific neck pain: a randomised controlled trial of efficacy. Forsch Komplementmed. 2008 Jun;15(3):138-45. doi: 10.1159/000132397. Epub 2008 Jun 4. PMID: 18617745

McReynolds TM, Sheridan BJ: Intramuscular ketorolac versus osteopathic manipulative treatment in the management of acute neck pain in the emergency department: a randomized clinical trial. J Am Osteopath Assoc. 2005 Feb;105(2):57-68. PMID: 15784928

Williams NH, Edwards RT, Linck P, Muntz R, Hibbs R, Wilkinson C, Russell I, Russell D, Hounsome B: Cost-utility analysis of osteopathy in primary care: results from a pragmatic randomized controlled trial. Fam Pract. 2004 Dec; 21(6):643-50. Epub 2004 Nov 5. PMID: 15531626

Williams NH, Wilkinson C, Russell I, Edwards RT, Hibbs R, Linck P, Muntz R: Randomized osteopathic manipulation study (ROMANS): pragmatic trial for spinal pain in primary care. Fam Pract. 2003 Dec; 20(6):662-9. PMID: 14701889

Licciardone JC, Stoll ST, Fulda KG, Russo DP, Siu J, Winn W, Swift J Jr: Osteopathic manipulative treatment for chronic low back pain: a randomized controlled trial. Spine (Phila Pa 1976). 2003 Jul 1;28(13):1355-62. PMID: 12838090

Burton AK, Tillotson KM, Cleary J: Single-blind randomised controlled trial of chemonucleolysis and manipulation in the treatment of symptomatic lumbar disc herniation. Eur Spine J. 2000 Jun; 9(3):202-7. PMID: 10905437

Andersson GB, Lucente T, Davis AM, Kappler RE, Lipton JA, Leurgans S: A comparison of osteopathic spinal manipulation with standard care for patients with low back pain. N Engl J Med. 1999 Nov 4;341(19):1426-31. PMID: 10547405

LBP Meta-Analyses and Reviews:

Thomas E, Cavallaro AR, Mani D, Bianco A, Palma A. The efficacy of muscle energy techniques in symptomatic and asymptomatic subjects: a systematic review. Chiropr Man Therap. 2019;27:35.

Franke H, Franke JD, Belz S, Fryer G. Osteopathic manipulative treatment for low back and pelvic girdle pain during and after pregnancy: A systematic review and meta-analysis. J Bodyw Mov Ther. 2017;21(4):752-762. PMID: 29037623

Schwerla F: Osteopathy for musculoskeletal pain: a systematic review. Clin Rheumatol. 2012 Jan;31(1):197-8. doi: 10.1007/s10067-011-1882-3. Epub 2011 Nov 3. PMID: 22048740

Licciardone JC, Brimhall AK, King LN: Osteopathic manipulative treatment for low back pain: a systematic review and meta-analysis of randomized controlled trials. BMC Musculoskelet Disord. 2005 Aug 4;6:43. Review. PMID: 16080794

LBP Pilot and Feasibility Studies:

Carrasco-martínez F, Ibáñez-vera AJ, Martínez-amat A, Hita-contreras F, Lomas-vega R. Short-term effectiveness of the flexion-distraction technique in comparison with high-velocity vertebral manipulation in patients suffering from low-back pain. Complement Ther Med. 2019;44:61-67. PMID: 31126577

Gao J, Caldwell J, Mclin K, Zhang M, Park D. Ultrasound Shear Wave Elastography to Assess Osteopathic Manipulative Treatment on the Iliocostalis Lumborum Muscle: A Feasibility Study. J Ultrasound Med. 2019; PMID: 31271461

Verhaeghe N, Schepers J, Van dun P, Annemans L. Osteopathic care for low back pain and neck pain: A cost-utility analysis. Complement Ther Med. 2018;40:207-213. PMID: 30219451

Polidori G, Kinne M, Mereu T, Beaumont F, Kinne M. Medical Infrared Thermography in back pain osteopathic management. Complement Ther Med. 2018;39:19-23. PMID: 30012388

Clark BC, Russ DW, Nakazawa M, et al. A randomized control trial to determine the effectiveness and physiological effects of spinal manipulation and spinal mobilization compared to each other and a sham condition in patients with chronic low back pain: Study protocol for The RELIEF Study. Contemp Clin Trials. 2018;70:41-52. PMID: 29792940

Seffinger MA, Hurwitz E, Quiamas J, Kitch A, Mervyn-cohen V, Lin E. Correlation of Personal Experience and Acquired Knowledge With Intent to Recommend Adjunctive Osteopathic Manipulative Treatment or Yoga for Patients With Chronic Low Back Pain. J Am Osteopath Assoc. 2018;118(11):738-745. PMID: 30398571

Galbraith W, Smith M, Seffinger MA. Treating Patients With Low Back Pain: Evidence vs Practice. J Am Osteopath Assoc. 2018;118(7):486-487. PMID: 29946671

Vismara L, Cimolin V, Menegoni F, Zaina F, Galli M, Negrini S, Villa V, Capodaglio P: Osteopathic manipulative treatment in obese patients with chronic low back pain: a pilot study. Man Ther. 2012 Oct;17(5):451-5. doi: 10.1016/j.math.2012.05.002. Epub 2012 May 31. PMID: 22658268

Degenhardt BF, Darmani NA, Johnson JC, Towns LC, Rhodes DC, Trinh C, McClanahan B, DiMarzo V: Role of osteopathic manipulative treatment in altering pain biomarkers: a pilot study. J Am Osteopath Assoc. 2007 Sep;107(9):387-400. PMID: 17908831

LBP Case Reports, Case Series and Other Studies:

Alexandre K, Channell MK. Osteopathic Approach to the Treatment of a Patient With an Atypical Presentation of Coccydynia. J Am Osteopath Assoc. 2019;119(6):395-400. PMID: 31135868

Kanze D. An Osteopathic Approach to Uterine-Induced Low Back Pain: A Case Report. The AAO Journal. 2019; 29(3): 23-26.

Origo D, Tarantino AG, Nonis A, Vismara L. Osteopathic manipulative treatment in chronic coccydynia: A case series. J Bodyw Mov Ther. 2018;22(2):261-265. PMID: 29861217

Lewis D, Summers G. An Osteopathic Approach to Low Back Pain and Short Leg Syndrome in a Patient with Traumatic Brain Injury Following Motor Vehicle Crash: A Case Report. The AAO Journal. 2018; 28(3):12-17.

Smith M, Galbraith W, Blumer J. Reducing Low Back and Posterior Pelvic Pain During and After Pregnancy Using OMT. J Am Osteopath Assoc. 2018;118(7):487-488. PMID: 29946672

Jazayeri S, Seffinger M. Myofascial Release Therapy Beneficial for Patients With Chronic Low Back Pain. J Am Osteopath Assoc. 2018;118(5):350-351. PMID: 29710362

Wilson D, Gorham J, Lamb T, Lui S, T Daniel. Osteopathic Manipulation Improves Functional Status in Patients With Non-Specific Chronic Back Pain in a Rural Outpatient Setting. The AAO Journal. 2018; 28(2): 29-33.

King HH. Addition of Osteopathic Visceral Manipulation to OMT for Low Back Pain Decreases Pain and Increases Quality of Life. J Am Osteopath Assoc. 2017;117(5):333-334. PMID: 28459483

Asahi MG, Seffinger MA. Noninvasive Interventions Efficacious in Reducing Symptoms of Low Back Pain. J Am Osteopath Assoc. 2017;117(5):335-336. PMID: 28459485

Bohr C, Seffinger MA. Cost-Effective Management of Low Back and Joint Pain by Specialty. J Am Osteopath Assoc. 2017;117(5):332. PMID: 28459481

Snider KT, Johnson JC, Degenhardt BF, Snider EJ: Low back pain, somatic dysfunction, and segmental bone mineral density T-score variation in the lumbar spine. J Am Osteopath Assoc. 2011 Feb;111(2):89-96. PMID: 21357494

Ellestad SM, Nagle RV, Boesler DR, Kilmore MA: Electromyographic and skin resistance responses to osteopathic manipulative treatment for low-back pain. J Am Osteopath Assoc. 1988 Aug; 88(8):991-7. PMID: 2975645

Pediatrics

Children respond very well to osteopathic treatment and will benefit from a treatment without side effects.

Marinelli B et al: Osteopathic manipulation treatment improves cerebro–splanchnic oximetry in late preterm infants. Molecules. 2019;24:3221. doi: 10.3390/molecules24183221. PMID: 31487945

Hendriksz T, Pierce-talsma S. Osteopathic Manipulative Medicine Use in Pediatric Patients With Pertussis. J Am Osteopath Assoc. 2019;119(2):e9-e10. PMID: 30688357

Marinelli B, Pluchinotta F, Cozzolino V, et al. Osteopathic Manipulation Treatment Improves Cerebro-splanchnic Oximetry in Late Preterm Infants. Molecules. 2019;24(18) PMID: 31487945

Noto-bell L, Vogel BN, Senn DE. Effects of Post-Isometric Relaxation on Ankle Plantarflexion and Timed Flutter Kick in Pediatric Competitive Swimmers. J Am Osteopath Assoc. 2019;119(9):569-577.

Barni A, Zecchillo D, Uberti S, Ratti S. Osteopathic Manipulative Treatment in a Paediatric Patient with Oesophageal Atresia and Tracheo-Oesophageal Fistula. Case Rep Gastroenterol. 2019;13(1):178-184. PMID: 31123444

Vismara L, Manzotti A, Tarantino AG, et al. Timing of oral feeding changes in premature infants who underwent osteopathic manipulative treatment. Complement Ther Med. 2019;43:49-52. PMID: 30935554

Brurberg KG, Dahm KT, Kirkehei I. Manipulation techniques for infant torticollis. Tidsskr Nor Laegeforen. 2019;138(1). PMID: 30644674

Tobey A, Kozar A. Frequency of Somatic Dysfunction in Infants with Tongue-Tie: A Retrospective Chart Review. The AAO Journal. 2018; 28(4):10-14.

Heineman, K. Osteopathic Manipulative Treatment in the Management of Pediatric Headache and Orthodontic Intervention: A Case Report. 2018; 28(1): 15-18.

Cuevas KM, Balbo J, Duval K, Beverly EA. Neurobiology of Sexual Assault and Osteopathic Considerations for Trauma-Informed Care and Practice. J Am Osteopath Assoc. 2018;118(2):e2-e10. PMID: 29227505

James SJ, Hudnall J. Use of the Fascial Distortion Model to Evaluate a Limp in a Child. J Am Osteopath Assoc. 2017;117(6):399-402. PMID: 28556863

Carls C, Krajacic P. Bridging the Gap: An Osteopathic Primary Care-Centered Approach to Duchenne Muscular Dystrophy. J Am Osteopath Assoc. 2017;117(6):377-385. PMID: 28556860

Feely RA, Kapraun HE. Progressive Infantile Scoliosis Managed With Osteopathic Manipulative Treatment. J Am Osteopath Assoc. 2017;117(9):595-599. PMID: 29946659

Pierce-talsma S, Peña N. Condylar Decompression Technique for Infants. J Am Osteopath Assoc. 2017;117(11):e136. PMID: 29084327

Lanaro D, Ruffini N, Manzotti A, Lista G. Osteopathic manipulative treatment showed reduction of length of stay and costs in preterm infants: A systematic review and meta-analysis. Medicine (Baltimore). 2017;96(12):e6408. PMID: 28328840

Bagagiolo D, Didio A, Sbarbaro M, Priolo CG, Borro T, Farina D: Osteopathic Manipulative Treatment in Pediatric and Neonatal Patients and Disorders: Clinical Considerations and Updated Review of the Existing Literature. Am J Perinatol. 2016 Sep; 33(11): 1050-4. PMID: 27603533

Pizzolorusso G et al: Osteopathic evaluation of somatic dysfunction and craniosacral strain pattern among preterm and term newborns. J Am Osteopath Assoc. 2013 Jun;113(6):462-7. PMID: 23739757

Cerritelli F, et al: Effect of osteopathic manipulative treatment on length of stay in a population of preterm infants: a randomized controlled trial. BMC Pediatr. 2013 Apr 26;13:65. doi: 10.1186/1471-2431-13-65. PMID: 23622070

Cerritelli F et al: Effectiveness of osteopathic manipulative treatment in neonatal intensive care units: protocol for a multicentre randomised clinical trial. BMJ Open. 2013 Feb 20;3(2). doi:pii: e002187. 10.1136/bmjopen-2012-002187. Print 2013. PMID: 23430598

Lund GC, Edwards G, Medlin B, Keller D, Beck B, Carreiro JE: Osteopathic manipulative treatment for the treatment of hospitalized premature infants with nipple feeding dysfunction. J Am Osteopath Assoc. 2011 Jan;111(1):44-8. Review. PMID: 21258016

Guiney PA, Chou R, Vianna A, Lovenheim J: Effects of osteopathic manipulative treatment on pediatric patients with asthma: a randomized controlled trial. J Am Osteopath Assoc. 2005 Jan;105(1):7-12. PMID: 15710659

Mills MV, Henley CE, Barnes LL, Carreiro JE, Degenhardt BF: The use of osteopathic manipulative treatment as adjuvant therapy in children with recurrent acute otitis media. Arch Pediatr Adolesc Med. 2003 Sep;157(9):861-6. PMID: 12963590

OB-GYN

Pregnant patients often experience significant pain which can indicate pelvic problems which could lead to longer deliveries or c-sections. Osteopathic manipulation is a non-pharmaceutical intervention that will not harm the fetus.

Martingano D, Ho S, Rogoff S, Chang G, Aglialoro GC. Effect of Osteopathic Obstetrical Management on the Duration of Labor in the Inpatient Setting: A Prospective Study and Literature Review. J Am Osteopath Assoc. 2019;119(6):371-378. PMID: 31135865

Cabrera K, Darwish A, Lurz K, McClain R, McClain E, Cox J, Segars L. Osteopathic Structural Findings in Women During Menstruation. The AAO Journal. 2019; 29(1): 7-13.

Martingano D, Ramírez LC, Bjurlin MA. Osteopathic Evaluation of Urinary Retention Caused by Atypical Presentation of Invasive Cervical Cancer Mimicking Primary Urothelial Tumor. J Am Osteopath Assoc. 2018;118(10):685-688. PMID: 30304339

Ruffo A, Blumer J. Reducing Cesarean Delivery Rates and Length of Labor by Addressing Pelvic Shape. J Am Osteopath Assoc. 2018;118(7):489-490. PMID: 29946674

Smith M, Galbraith W, Blumer J. Reducing Low Back and Posterior Pelvic Pain During and After Pregnancy Using OMT. J Am Osteopath Assoc. 2018;118(7):487-488. PMID: 29946672

Sheraton A, Streckfuss J, Grace S. Experiences of pregnant women receiving osteopathic care. J Bodyw Mov Ther. 2018;22(2):321-327. PMID: 29861226

Martingano D, Canepa H, Fararooy S, et al. Somatic Dysfunction in the Diagnosis of Uncommon Ectopic Pregnancies: Surgical Correlation and Comparison With Related Pathologic Findings. J Am Osteopath Assoc. 2017;117(2):86-97. PMID: 28134961

Russo G, Remonato A, Remonato R, Zanier E. Hypnosis and Osteopathic Manipulative Treatment for Visual Disorders During Pregnancy: A Case Report. Adv Mind Body Med. 2017;31(3):23-27. PMID: 28987037

Daraï C, Bendifallah S, Foulot H, Ballester M, Chabbert-buffet N, Daraï E. [Impact of osteopathic manipulative therapy in patient with deep with colorectal endometriosis: A classification based on symptoms and quality of life]. Gynecol Obstet Fertil Senol. 2017;45(9):472-477. PMID: 28869181

Goyal K, Goyal M, Narkeesh K, et al. The effectiveness of osteopathic manipulative treatment in an abnormal uterine bleeding related pain and health related quality of life (HR-QoL) – A case report. J Bodyw Mov Ther. 2017;21(3):569-573. PMID: 28750966

Licciardone JC. Osteopathic Manipulative Treatment During the Third Trimester of Pregnancy. J Am Osteopath Assoc. 2017;117(5):289-290. PMID: 28459477

Marx S. [Chronic pelvic pain syndrome : Treatment options using osteopathy]. Urologe A. 2017;56(8):1008-1016. PMID: 28401276

Hall H, Cramer H, Sunberg T, Adams J, Moore C, Sibbritt D, Lauche R: The effectiveness of complementary manual therapies for pregnancy-related back and pelvic pain: A systematic review with meta-analysis. Medicine (Blatimore). 2016 Sep; 95(38): e4723. PMID: 27661020

Hastings V, McCallister AM, Curtis SA, Valant RJ: Efficacy of Osteopathic Manipulative Treatment for Management of Postpartum Pain. J Am Osteopath Assoc. August 2016. Vol. 116, 502-509. DOI: 10.7556/jaoa.2016.103. PMID: 27455099

Martingano D: Management of Cesarean Deliveries and Cesarean Scars with Osteopathic Manipulative Treatment: A Brief Report. J Am Osteopath Assoc. July 2016, Vol. 116, e22-30. DOI: 10.7556/jaoa.2016.093. PMID: 27367961

Martingano D, Gurm H, Oliff A, Martingano FX, Aglialoro G: Osteopathic Approach to the Diagnosis of Appendiceal Mucinous Cystadenocarcinoma Mimicking Primary Ovarian Malignant Neoplasm. J Am Osteopath Assoc. 2016 Jul 1;116(7):480-4. doi: 10.7556/jaoa.2016.092. PMID: 27367953

Martingano D, Eisenberg J, Aglialoro GC: Management of Acute Isolated Soleal Vein Thrombosis in a Pregnant Patient With an Osteopathic Approach to Evaluation. J Am Osteopath Assoc. 2016 Jan;116(1):50-4. doi: 10.7556/jaoa.2016.006. PMID: 26745564

Hensel KL, Buchanan S, Brown SK, Rodriguez M, Cruser DA: Pregnancy Research on Osteopathic Manipulation Optimizing Treatment Effects: the PROMOTE study. Am J Obstet Gynecol. 2014 Jul 25. pii: S0002 9378(14)00792-3. doi: 10.1016/j.ajog.2014.07.043. [Epub ahead of print] PMID: 25068560

Hensel KL, Pacchia CF, Smith ML: Acute improvement in hemodynamic control after osteopathic manipulative treatment in the third trimester of pregnancy. Complement Ther Med. 2013 Dec;21(6):618-26. doi: 10.1016/j.ctim.2013.08.008. Epub 2013 Aug 30. PMID: 24280470

Licciardone JC, Aryal S: Prevention of Progressive Back-Specific Dysfunction During Pregnancy: An Assessment of Osteopathic Manual Treatment Based on Cochrane Back Review Group Criteria. J Am Osteopath Assoc. 2013 Oct;113(10):728-736. PMID: 24084800

Licciardone JC, Buchanan S, Hensel KL, King HH, Fulda KG, Stoll ST: Osteopathic manipulative treatment of back pain and related symptoms during pregnancy: a randomized controlled trial. Am J Obstet Gynecol. 2010 Jan;202(1):43.e1-8. doi: 10.1016/j.ajog.2009.07.057. Epub 2009 Sep 20. PMID: 19766977

King HH, Tettambel MA, Lockwood MD, Johnson KH, Arsenault DA, Quist R: Osteopathic manipulative treatment in prenatal care: a retrospective case control design study. J Am Osteopath Assoc. 2003 Dec;103(12):577-82. PMID: 14740980

Boesler D, Warner M, Alpers A, Finnerty EP, Kilmore MA: Efficacy of high-velocity low-amplitude manipulative technique in subjects with low-back pain during menstrual cramping. J Am Osteopath Assoc. 1993 Feb; 93(2):203-8, 213-4. PMID: 8432669

Osteopathic Cranial Manipulative Medicine

Further discussion of research into Cranial Osteopathy here

Mcaree M, Dunn A, Furtado J, et al. Osteopathic Cranial Manipulative Medicine and the Blood-Brain Barrier: A Mechanistic Approach to Alzheimer Prevention. J Am Osteopath Assoc. 2019: PMID: 31081865

Easterbrook S, Keys J, Talsma J, Pierce-talsma S. Osteopathic Manipulative Treatment for Temporomandibular Disorders. J Am Osteopath Assoc. 2019;119(6):e29-e30. PMID: 31135870

Mcaree M, Dunn A, Furtado J, et al. Osteopathic Cranial Manipulative Medicine and the Blood-Brain Barrier: A Mechanistic Approach to Alzheimer Prevention. J Am Osteopath Assoc. 2019; PMID: 31081865

Patel KG, Sabini RC. Safety of Osteopathic Cranial Manipulative Medicine as an Adjunct to Conventional Postconcussion Symptom Management: A Pilot Study. J Am Osteopath Assoc. 2018;118(6):403-409. PMID: 29710088

Warren C, Keys J, Pierce-talsma S. Osteopathic Cranial Manipulative Medicine in the Setting of Concussion. J Am Osteopath Assoc. 2018;118(6):e41-e42. PMID: 29809262

Zwibel H, Leder A, Yao S, Finn C. Concussion Evaluation and Management: An Osteopathic Perspective. J Am Osteopath Assoc. 2018;118(10):655-661. PMID: 30242340

King HH. CSF Flow Has a Significant Respiratory Component. J Am Osteopath Assoc. 2018;118(1):52-53. PMID: 29309096

Gesslbauer C, Vavti N, Keilani M, Mickel M, Crevenna R. Effectiveness of osteopathic manipulative treatment versus osteopathy in the cranial field in temporomandibular disorders – a pilot study. Disabil Rehabil. 2018;40(6):631-636. PMID: 28029069

Shanahan LK, Raines SG, Coggins RL, Moore T, Carnes M, Griffin L. Osteopathic Manipulative Treatment in the Management of Isaacs Syndrome. J Am Osteopath Assoc. 2017;117(3):194-198. PMID: 28241332

Sherman T, Qureshi Y, Bach A. Osteopathic Manipulative Treatment to Manage Ophthalmic Conditions. J Am Osteopath Assoc. 2017;117(9):568-575. PMID: 28846123

Bach A, Bach M, Frankel S. Effect of Osteopathic Cranial Manipulative Medicine on Visual Function. J Am Osteopath Assoc. 2017;117(11):681-682. PMID: 29084319

Tang MY, King HH. Effectiveness of OMT and OCMM for Temporomandibular Disorders. J Am Osteopath Assoc. 2017;117(5):334-335. PMID: 28459484

Pierce-talsma S, Peña N. Condylar Decompression Technique for Infants. J Am Osteopath Assoc. 2017;117(11):e136. PMID: 29084327

King HH. Manual Craniosacral Therapy May Reduce Symptoms of Migraine Headache. J Am Osteopath Assoc. 2017;117(1):59. PMID: 28055092

Tang MY, King HH. Manual Therapy Lowers Psychological Aggravations in Patients WIth Tension-Type Headache. J Am Osteopath Assoc. 2017;117(1):59-60. PMID: 28055093

D’ippolito M, Tramontano M, Buzzi MG. Effects of Osteopathic Manipulative Therapy on Pain and Mood Disorders in Patients With High-Frequency Migraine. J Am Osteopath Assoc. 2017;117(6):365-369. PMID: 28556858

King HH. Recognizing the Value of Manual Therapy Interventions for Head Pain. J Am Osteopath Assoc. 2017;117(1):60-62. PMID: 28055094

Halimi M, Leder A, Mancini JD. Integration of Osteopathic Manual Treatments in Management of Cervical Dystonia with Tremor: A Case Series. Tremor Other Hyperkinet Mov (N Y). 2017;7:435. PMID: 28119789

Gesslbauer C, et al: Effectiveness of osteopathic manipulative treatment versus osteopathy in the cranial field in temporomandibular disorders – a pilot study. Disabil Rehabil. 2016 Dec 28:1-6. doi: 10.1080/09638288.2016.1269368. [Epub ahead of print]

Martins WR, Diniz LR, Blasczyk JC, Lagoa KF, Thomaz S, Rodrigues ME, de Oliveira RJ, Bonini-Rocha AC: Immediate changes in electroencephalography activity in individuals with nonspecific chronic low back pain after cranial osteopathic manipulative treatment: study protocol of a randomized, controlled crossover trial. BMC Complement Altern Med. 2015 Jul 13;15:223. doi: 10.1186/s12906-015-0732-2. PMID: 26165865

Cardoso-de-Mello-E-Mello-Ribeiro AP, Rodríguez-Blanco C, Riquelme-Agulló I, Heredia-Rizo AM, Ricard F, Oliva-Pascual-Vaca Á: Effects of the Fourth Ventricle Compression in the Regulation of the Autonomic Nervous System: A Randomized Control Trial. Evid Based Complement Alternat Med. 2015;2015:148285. doi: 10.1155/2015/148285. Epub 2015 Jun 14. PMID: 26199632

Fraix M, Gordon A, Graham V, Hurwitz E, Seffinger MA: Use of the SMART Balance Master to quantify the effects of osteopathic manipulative treatment in patients with dizziness. J Am Osteopath Assoc. 2013 May;113(5):394-403. PMID: 23667193

King HH: Cranial osteopathic manipulative medicine’s growing evidence base. J Am Osteopath Assoc. 2012 Jan;112(1):9. PMID: 22302741

Jäkel A, von Hauenschild P: Therapeutic effects of cranial osteopathic manipulative medicine: a systematic review. J Am Osteopath Assoc. 2011 Dec;111(12):685-93. Review. PMID: 22182954

Shi X, Rehrer S, Prajapati P, Stoll ST, Gamber RG, Downey HF: Effect of cranial osteopathic manipulative medicine on cerebral tissue oxygenation. J Am Osteopath Assoc. 2011 Dec;111(12):660-6. PMID: 22182951

Crow WT, King HH, Patterson RM, Giuliano V: Assessment of calvarial structure motion by MRI. Osteopath Med Prim Care. 2009 Sep 4;3:8. doi: 10.1186/1750-4732-3-8. PMID: 19732453

Schabert E, Crow WT: Impact of osteopathic manipulative treatment on cost of care for patients with migraine headache: a retrospective review of patient records. J Am Osteopath Assoc. 2009 Aug;109(8):403-7. PMID: 19706829

Moskalenko YE, Kravchenko TI, Vainshtein GB, Halvorson P, Feilding A, Mandara A, Panov AA, Semernya VN. Slow-wave oscillations in the craniosacral space: a hemoliquorodynamic concept of origination. Neurosci Behav Physiol. 2009 May;39(4):377-81. doi: 10.1007/s11055-009-9140-8. Epub 2009 Apr 2. PMID: 19340579

Nelson KE, Sergueef N, Glonek T: The effect of an alternative medical procedure upon low-frequency oscillations in cutaneous blood flow velocity. J Manipulative Physiol Ther. 2006 Oct;29(8):626-36. PMID: 17045096

Nelson KE, Sergueef N, Glonek T: Recording the rate of the cranial rhythmic impulse. J Am Osteopath Assoc. 2006 Jun;106(6):337-41. PMID: 16790539

Sergueef N, Nelson KE, Glonek T: Palpatory diagnosis of plagiocephaly. Complement Ther Clin Pract. 2006 May;12(2):101-10. Epub 2006 Mar 29. PMID: 16648087

Sergueef N, Nelson KE, Glonek T: The effect of cranial manipulation on the Traube-Hering-Mayer oscillation as measured by laser doppler flowmetry. Altern Ther Health Med. 2002 Nov-Dec;8(6):74-6. PMID: 12440842 (abstract)

Oleski SL, Smith GH, Crow WT. Radiographic evidence of cranial bone mobility. Cranio. 2002 Jan;20(1):34-8.

Nelson KE, Sergueef N, Lipinski CM, Chapman AR, Glonek T. Cranial rhythmic impulse related to the Traube-Hering-Mayer oscillation: comparing laser-Doppler flowmetry and palpation. J Am Osteopath Assoc. 2001 Mar;101(3):163-73.

Moskalenko IuE, Frymann V, Vaĭnshteĭn GB, Semernia VN, Kravchenko TI, Markovets SP, Panov AA, Maĭorova NF. [Slow rhythmic oscillations within the human cranium: phenomenology, origin, informational significance]. [Article in Russian]. Fiziol Cheloveka. 2001 Mar-Apr;27(2):47-55. PMID: 11544869

Upledger JE, Karni Z: Mechano-Electric Patterns During Craniosacral Osteopathic Diagnosis. J Am Osteopath Assoc. 1979 Jul;78(11):782-91. PMID: 582820

Frymann VM: Learning difficulties of children viewed in the light of the osteopathic concept. JAOA Vol 76 Sep 1976.

Retzlaff EW, Michael D, Roppel R, Mitchell F. Proceedings: The structures of cranial bone sutures. J Am Osteopath Assoc. 1976 Feb;75(6):607-8. PMID: 814155

Popevec JP, Biggert TP, Retzlaff EW. Proceedings: Histological techniques for cranial bone studies. J Am Osteopath Assoc. 1976 Feb;75(6):606-7. PMID: 55432

Retzlaff EW, Michael DK, Roppel RM. Cranial bone mobility. J Am Osteopath Assoc. 1975 May;74(9):869-73. PMID: 804505

Michael DK, Retzlaff EW. A preliminary study of cranial bone movement in the squirrel monkey. J Am Osteopath Assoc. 1975 May;74(9):866-9. PMID: 804504

Frymann VM. A study of the rhythmic motions of the living cranium. J Am Osteopath Assoc. 1971 May;70(9):928-45.

Pulmonology

Breathing is dependent on biomechanical factors including diaphragm and rib function, along with lympathic drainage of the lung parenchyma.

Maskey-Warzechowska M et al: (2019) Effects of Osteopathic Manual Therapy on Hyperinflation in Patients with Chronic Obstructive Pulmonary Disease: A Randomized Cross-Over Study. In: Pokorski M. (eds) Pulmonology. Advances in Experimental Medicine and Biology, vol 1222. Springer, Cham. PMID: 31541364

Liem T. Osteopathic Manipulative Treatment for Pertussis in the 19th and 20th Centuries: A Structured Historical Literature Review. J Am Osteopath Assoc. 2019;119(2):116-125. PMID: 30688349

Lorenzo S, Nicotra CM, Mentreddy AR, et al. Assessment of Pulmonary Function After Osteopathic Manipulative Treatment vs Standard Pulmonary Rehabilitation in a Healthy Population. J Am Osteopath Assoc. 2019. PMID: 30741314

Bordoni B. Doming the Diaphragm in a Patient With Multiple Sclerosis. J Am Osteopath Assoc. 2019;119(5):282a-283. PMID: 31034063

Chin AJ, Fischione AD, Shilian R, et al. Tolerance of Rib Raising Among Hospitalized Patients: A Pilot Study. J Am Osteopath Assoc. 2019;119(1):19-23. PMID: 30556829

Buscemi A, Pennisi V, Rapisarda A, Pennisi A, Coco M. Efficacy of osteopathic treatment in patients with stable moderate-to-severe chronic obstructive pulmonary disease: a randomized controlled pilot study. J Complement Integr Med. 2019. PMID: 31442204

Bordoni B. Lymphatic Pump Manipulation in Patients with Chronic Obstructive Pulmonary Disease. Cureus. 2019;11(3):e4232. PMID: 31123654
Mancini D, Cesari M, Lunghi C, Benigni AM, Antonelli incalzi R, Scarlata S. Ultrasound Evaluation of Diaphragmatic Mobility and Contractility After Osteopathic Manipulative Techniques in Healthy Volunteers: A Prospective, Randomized, Double-Blinded Clinical Trial. J Manipulative Physiol Ther. 2019;42(1):47-54. PMID: 30955907

Lorenzo S, Nicotra CM, Mentreddy AR, et al. Assessment of Pulmonary Function After Osteopathic Manipulative Treatment vs Standard Pulmonary Rehabilitation in a Healthy Population. J Am Osteopath Assoc. 2019; PMID: 30741314

Liem T. Osteopathic Manipulative Treatment for Pertussis in the 19th and 20th Centuries: A Structured Historical Literature Review. J Am Osteopath Assoc. 2019;119(2):116-125. PMID: 30688349

Chin AJ, Fischione AD, Shilian R, et al. Tolerance of Rib Raising Among Hospitalized Patients: A Pilot Study. J Am Osteopath Assoc. 2019;119(1):19-23. PMID: 30556829

Uysal SC, Tüzün EH, Eker L, Angın E. Effectiveness of the muscle energy technique on respiratory muscle strength and endurance in patients with fibromyalgia. J Back Musculoskelet Rehabil. 2019;32(3):411-419. PMID: 30475751

Pierce-talsma S, Talsma J, Ferrill H. An Osteopathic Approach to Rib Somatic Dysfunction in Respiratory Disorders. J Am Osteopath Assoc. 2018;118(10):e94-e95. PMID: 30335880

King HH. Osteopathic Manipulation Shown to Improve Upper Airway Stabilization. J Am Osteopath Assoc. 2018;118(5):348a-349. PMID: 29710360

Pierce-talsma S, Talsma J, Ferrill H. An Osteopathic Approach to Rib Somatic Dysfunction in Respiratory Disorders. J Am Osteopath Assoc. 2018;118(10):e94-e95. PMID: 30335880

Lewis D. Osteopathic Evaluation and Post-Surgical Rehabilitation Approach in a Patient With Myelopathy and Tetraparesis Related to Cervical Ependymoma: A Case Report. The AAO Journal. 2018; 28(2): 39-43.

Jacq O, Arnulf I, Similowski T, Attali V. Upper airway stabilization by osteopathic manipulation of the sphenopalatine ganglion versus sham manipulation in OSAS patients: a proof-of-concept, randomized, crossover, double-blind, controlled study. BMC Complement Altern Med. 2017;17(1):546. PMID: 29262824

Goyal M, Goyal K, Narkeesh K, et al. Efficacy of Osteopathic Manipulative Treatment Approach in the Patient with Pulmonary Fibrosis in Critical Care Outpatient Department. Indian J Crit Care Med. 2017;21(7):469-472. PMID: 28808371

Noll DR, Degenhardt BF, Morley TF, Blais FX, Hortos KA, Hensel K, Johnson JC, Pasta DJ, Stoll ST: Efficacy of osteopathic manipulation as an adjunctive treatment for hospitalized patients with pneumonia: a randomized controlled trial. Osteopath Med Prim Care. 2010 Mar 19;4:2. doi: 10.1186/1750-4732-4-2. PMID: 20302619

Noll DR, Degenhardt BF, Johnson JC, Burt SA: Immediate effects of osteopathic manipulative treatment in elderly patients with chronic obstructive pulmonary disease. J Am Osteopath Assoc. 2008 May;108(5):251-9. PMID: 18519835

Post-Operative Recovery

Osteopathy can reduce pain and support recovery by reducing complications, showing its utility in combination with conventional interventions.

Chvetzoff G, Berthier A, Blanc E, et al. [Osteopathy for chronic pain after breast cancer surgery: A monocentric randomised study]. Bull Cancer. 2019;106(5):436-446. PMID: 31005246

Fong K, Rummel T. Rescued Root Canal: A Case Report on OMT for Jaw Pain Following Repeat Root Canal Procedure. The AAO Journal. 2019; 29(1): 15-17.

Gray RE, Kasper K. Osteopathic Manipulative Treatment as a Novel Way to Manage Postvasectomy Pain Syndrome. J Am Osteopath Assoc. 2018. PMID: 30383152

Peña N, Prieto H, Pierce-talsma S. OMT for Cancer Patients After Bowel Resection. J Am Osteopath Assoc. 2018;118(1):e1. PMID: 29309103

Gray RE, Kasper K. Osteopathic Manipulative Treatment as a Novel Way to Manage Postvasectomy Pain Syndrome. J Am Osteopath Assoc. 2018; PMID: 30383152

King HH. Benefit of OMT in Patients Who Underwent Heart Surgery. J Am Osteopath Assoc. 2017;117(5):332-333. PMID: 28459482

Ignatowicz A, Berkowitz M. Imaging Evidence Demonstrating Effectiveness of Osteopathic Visceral Manipulation Techniques in Treating Pseudo-Obstruction. The AAO Journal. 2017; 27(1): 7-10.

Hess N. Osteopathic Manipulative Treatment for Nausea and Vomiting Following Fine Needle Aspiration of the Neck. The AAO Journal. 2017; 27(1): 12-16.

Sposato NS, Bjerså K. Osteopathic Manipulative Treatment in Surgical Care: Short Review of Research Publications in Osteopathic Journals During the Period 1990 to 2017. J Evid Based Integr Med. 2018;23:2515690X18767671. PMID: 29637792

Wieting JM, Beal C, Roth GL, Gerbis S, Dillard L, Gilliland D, Rowan J: The Effect of Osteopathic Manipulative Treatment on Postoperative Medical and Functional Recovery of Coronary Artery Bypass Graft Patients. J Am Osteopath Assoc. 2013 May;113(5):384-393. PMID: pending

Baltazar GA, Betler MP, Akella K, Khatri R, Asaro R, Chendrasekhar A: Effect of osteopathic manipulative treatment on incidence of postoperative ileus and hospital length of stay in general surgical patients. J Am Osteopath Assoc. 2013 Mar;113(3):204-9. PMID: 23485980

O-Yurvati AH, Carnes MS, Clearfield MB, Stoll ST, McConathy WJ: Hemodynamic effects of osteopathic manipulative treatment immediately after coronary artery bypass graft surgery. J Am Osteopath Assoc. 2005 Oct;105(10):475-81. PMID: 16314680

Licciardone JC, Stoll ST, Cardarelli KM, Gamber RG, Swift JN Jr, Winn WB: A randomized controlled trial of osteopathic manipulative treatment following knee or hip arthroplasty. J Am Osteopath Assoc. 2004 May;104(5):193-202. PMID: 15176518

Lymphatic Function

These basic science articles look at models for lymphatic function and osteopathic approaches to augment drainage.

King HH. Lymphatic Vessels Found in the Brain-Osteopathic Considerations, Part 2: Now in Humans and Monkeys. J Am Osteopath Assoc. 2018;118(1):53. PMID: 29309097

Kilgore T, Malia M, Di giacinto B, Minter S, Samies J. Adjuvant Lymphatic Osteopathic Manipulative Treatment in Patients With Lower-Extremity Ulcers: Effects on Wound Healing and Edema. J Am Osteopath Assoc. 2018;118(12):798-805. PMID: 30476991

Castillo R, Schander A, Hodge LM. Lymphatic Pump Treatment Mobilizes Bioactive Lymph That Suppresses Macrophage Activity In Vitro. J Am Osteopath Assoc. 2018;118(7):455-461. PMID: 29946663

Franzini D, Cuny LA, Pierce-talsma S. Osteopathic Lymphatic Pump Techniques. J Am Osteopath Assoc. 2018;118(7):e43-e44. PMID: 29946678

Castillo R, Schander A, Hodge LM. Lymphatic Pump Treatment Mobilizes Bioactive Lymph That Suppresses Macrophage Activity In Vitro. J Am Osteopath Assoc. 2018;118(7):455-461. PMID: 29946663

Anderson Z, Nuño V, Pierce-talsma S. An Osteopathic Approach to Stasis Dermatitis and Chronic Venous Insufficiency. J Am Osteopath Assoc. 2018;118(12):e204-e205. PMID: 30476998

Lewis D. Advancing the Understanding and Treatment of the Thoracic Inlet and Incorporation of a New Still Technique—Part 2. The AAO Journal. 2018; 28(1): 9-14.

Castillo R, Schander A, Hodge LM. Lymphatic Pump Treatment Mobilizes Bioactive Lymph That Suppresses Macrophage Activity In Vitro. J Am Osteopath Assoc. 2018;118(7):455-461. PMID: 29946663

King HH. Lymphatic Vessels Found in the Brain-Osteopathic Considerations, Part 2: Now in Humans and Monkeys. J Am Osteopath Assoc. 2018;118(1):53. PMID: 29309097

Lewis D. Advancing the Understanding and Treatment of the Thoracic Inlet and Incorporation of a New Still Technique—Part 1. The AAO Journal. 2017; 27(3):19-24.

McSweeney TP, Thomson OP, Johnston R: The immediate effects of sigmoid colon manipulation on pressure pain thresholds in the lumbar spine. J Bodyw Mov Ther. 2012 Oct;16(4):416-23. doi: 10.1016/j.jbmt.2012.02.004. Epub 2012 Mar 28. PMID: 23036875

Hodge LM: Osteopathic lymphatic pump techniques to enhance immunity and treat pneumonia. Int J Osteopath Med. 2012 Mar;15(1):13-21. PMID: 22977459

Schander A, Downey HF, Hodge LM: Lymphatic pump manipulation mobilizes inflammatory mediators into lymphatic circulation. Exp Biol Med (Maywood). 2012 Jan 1;237(1):58-63. doi: 10.1258/ebm.2011.011220. Epub 2011 Dec 14. PMID: 22169162

Hodge LM, Downey HF: Lymphatic pump treatment enhances the lymphatic and immune systems. Exp Biol Med (Maywood). 2011 Oct 1;236(10):1109-15. doi: 10.1258/ebm.2011.011057. Epub 2011 Aug 24. Review. PMID: 21865405

Huff JB, Schander A, Downey HF, Hodge LM: Lymphatic pump treatment augments lymphatic flux of lymphocytes in rats. Lymphat Res Biol. 2010 Dec;8(4):183-7. doi: 10.1089/lrb.2010.0009. PMID: 21190489

Prajapati P, Shah P, King HH, Williams AG Jr, Desai P, Downey HF: Lymphatic pump treatment increases thoracic duct lymph flow in conscious dogs with edema due to constriction of the inferior vena cava. Lymphat Res Biol. 2010 Sep;8(3):149-54. doi: 10.1089/lrb.2009.0032. PMID: 20863267

Hodge LM, Bearden MK, Schander A, Huff JB, Williams A Jr, King HH, Downey HF: Lymphatic pump treatment mobilizes leukocytes from the gut associated lymphoid tissue into lymph. Lymphat Res Biol. 2010 Jun;8(2):103-10. doi: 10.1089/lrb.2009.0011. PMID: 20583872

Hodge LM, Bearden MK, Schander A, Huff JB, Williams A Jr, King HH, Downey HF: Lymphatic pump treatment mobilizes leukocytes from the gut associated lymphoid tissue into lymph. Lymphat Res Biol. 2010 Jun;8(2):103-10. doi: 10.1089/lrb.2009.0011. PMID: 20583872

Downey HF, Durgam P, Williams AG Jr, Rajmane A, King HH, Stoll ST: Lymph flow in the thoracic duct of conscious dogs during lymphatic pump treatment, exercise, and expansion of extracellular fluid volume. Lymphat Res Biol. 2008;6(1):3-13. doi: 10.1089/lrb.2007.1017. PMID: 18361766

Hodge LM, King HH, Williams AG Jr, Reder SJ, Belavadi T, Simecka JW, Stoll ST, Downey HF: Abdominal lymphatic pump treatment increases leukocyte count and flux in thoracic duct lymph. Lymphat Res Biol. 2007;5(2):127-33. PMID: 17935480

Breithaupt T, Harris K, Ellis J, Purcell E, Weir J, Clothier M, Boesler D: Thoracic lymphatic pumping and the efficacy of influenza vaccination in healthy young and elderly populations. J Am Osteopath Assoc. 2001 Jan;101(1):21-5. PMID: 11234217

Neurology

Osteopathy shows much promise in TBIs and other areas of neurology.

Deodato M, Guolo F, Monticco A, Fornari M, Manganotti P, Granato A. Osteopathic Manipulative Therapy in Patients With Chronic Tension-Type Headache: A Pilot Study. J Am Osteopath Assoc. 2019;

Gyer G, Michael J, Inklebarger J, Tedla JS. Spinal manipulation therapy: Is it all about the brain? A current review of the neurophysiological effects of manipulation. J Integr Med. 2019;17(5):328-337. PMID: 31105036

Origo D, Tarantino AG. Osteopathic manipulative treatment in pudendal neuralgia: A case report. J Bodyw Mov Ther. 2019;23(2):247-250. PMID: 31103103

Tamburella F, Piras F, Piras F, Spanò B, Tramontano M, Gili T. Cerebral Perfusion Changes After Osteopathic Manipulative Treatment: A Randomized Manual Placebo-Controlled Trial. Front Physiol. 2019;10:403. PMID: 31024346

Rist PM, Hernandez A, Bernstein C, et al. The Impact of Spinal Manipulation on Migraine Pain and Disability: A Systematic Review and Meta-Analysis. Headache. 2019;59(4):532-542.

Porcari B, Russo M, Naro A, et al. Effects of osteopathic manipulative treatment on patients with multiple sclerosis: A pilot study. Complement Ther Med. 2019;43:154-156. PMID: 30935523

Whalen J, Yao S, Leder A. A Short Review of the Treatment of Headaches Using Osteopathic Manipulative Treatment. Curr Pain Headache Rep. 2018;22(12):82. PMID: 30291550

Rizkalla MN, Henderson KK, Huntington-alfano K, et al. Does Osteopathic Manipulative Treatment Make a Neuropsychological Difference in Adults With Pain? A Rationale for a New Approach. J Am Osteopath Assoc. 2018;118(9):617-622. PMID: 30178052

Anderson Z, Hiserote RM, Pierce-talsma S. Doming the Diaphragm in a Patient With Multiple Sclerosis. J Am Osteopath Assoc. 2018;118(8):e83. PMID: 30073345

Cordano C, Armezzani A, Veroni J, et al. Osteopathic Manipulative Therapy and Multiple Sclerosis: A Proof-of-Concept Study. J Am Osteopath Assoc. 2018;118(8):531-536. PMID: 30073336

Whelan G, Johnston R, Millward C, Edwards DJ. The immediate effect of osteopathic cervical spine mobilization on median nerve mechanosensitivity: A triple-blind, randomized, placebo-controlled trial. J Bodyw Mov Ther. 2018;22(2):252-260. PMID: 29861216

Ponzo V, Cinnera AM, Mommo F, Caltagirone C, Koch G, Tramontano M. Osteopathic Manipulative Therapy Potentiates Motor Cortical Plasticity. J Am Osteopath Assoc. 2018;118(6):396-402. PMID: 29809257

Patel KG, Sabini RC. Safety of Osteopathic Cranial Manipulative Medicine as an Adjunct to Conventional Postconcussion Symptom Management: A Pilot Study. J Am Osteopath Assoc. 2018;118(6):403-409. PMID: 29710088

Espí-lópez GV, Ruescas-nicolau MA, Nova-redondo C, Benítez-martínez JC, Dugailly PM, Falla D. Effect of Soft Tissue Techniques on Headache Impact, Disability, and Quality of Life in Migraine Sufferers: A Pilot Study. J Altern Complement Med. 2018;24(11):1099-1107. PMID: 29708766

Papa L, Amodio A, Biffi F, Mandara A. Impact of osteopathic therapy on proprioceptive balance and quality of life in patients with dizziness. J Bodyw Mov Ther. 2017;21(4):866-872. PMID: 29037641

Fornari M, Carnevali L, Sgoifo A. Single Osteopathic Manipulative Therapy Session Dampens Acute Autonomic and Neuroendocrine Responses to Mental Stress in Healthy Male Participants. J Am Osteopath Assoc. 2017;117(9):559-567. PMID: 28846122

Cerritelli F, Lacorte E, Ruffini N, Vanacore N. Osteopathy for primary headache patients: a systematic review. J Pain Res. 2017;10:601-611. PMID: 28352200

Shanahan LK, Raines SG, Coggins RL, Moore T, Carnes M, Griffin L. Osteopathic Manipulative Treatment in the Management of Isaacs Syndrome. J Am Osteopath Assoc. 2017;117(3):194-198. PMID: 28241332

Difrancisco-donoghue J, Apoznanski T, De vries K, Jung MK, Mancini J, Yao S. Osteopathic manipulation as a complementary approach to Parkinson’s disease: A controlled pilot study. NeuroRehabilitation. 2017;40(1):145-151. PMID: 27814309

McCallister A, Brown C, Smith M, Ettlinger H: Osteopathic Manipulative Treatment for Somatic Dysfunciton after Acute Severe Traumatic Brain Injury. J Am Osteopath Assoc. December 2016. Vol. 116, 810-815. DOI: 10.7556/jaoa.2016.157. PMID: 27893148

Sandhouse ME, Shechtman D, Fecho G, Timoshkin EM: Effect of Osteopathic Cranial Manipulative Medicine on Visual Function. J Am Osteopath Assoc. 2016 Nov 1. 116 (11):706-714. DOI: 10.7556/jaoa.2016.141. PMID: 27802556

DiFrancisco-Donoghue J, Apoznanski T, de Vries K, Jung, MK, Mancini J, Yao S: Osteopathic manipulation as a complementary approach to Parkinson’s disease: A controlled pilot study. NeuroRehabilitation. 2016 Oct 31. PMID: 27814309

Cerritelli F, Ruffini N, Lacorte E, Vanacore N: Osteopathic manipulative treatment in neurological diseases: Systematic review of the literature. J Nerol Sci. 2016 Oct 15; 369:333-41. PMID: 27653920

Guernsey DT, Leder A, Yao S: Resolution of Concussion Symptoms after Osteopathic Manipulative Treatment: A Case Report. J Am Osteopath Assoc. March 2016, e13-17. DOI: 10.7556/jaoa.2016.036. PMID: 26927914

Arienti C, Daccò S, Piccolo I, Redaelli T: Osteopathic manipulative treatment is effective on pain control associated to spinal cord injury. Spinal Cord. 2011 Apr; 49(4):515-9. doi: 10.1038/sc.2010.170. Epub 2010 Dec 7. PMID: 21135862

Channell MK, Mueller LL, Hahn R: Management of chronic posttraumatic headache: a multidisciplinary approach. J Am Osteopath Assoc. 2009 Sep;109(9):509-13. PMID: 19767483

Geriatrics (see also Pulmonology)

Older patients often benefit from gentler bodywork approaches available to osteopathic physicians.

Brown ZJ, Martin SP, Carman R. Integrating Osteopathic Philosophy in Cancer Care. J Am Osteopath Assoc. 2019;119(6):391-394. PMID: 31135867

Forte ML, Maiers M. Differences in Function and Comorbidities Between Older Adult Users and Nonusers of Chiropractic and Osteopathic Manipulation: A Cross-sectional Analysis of the 2012 National Health Interview Survey. J Manipulative Physiol Ther. 2019;42(6):450-460.

Arienti C, Bosisio T, Ratti S, Miglioli R, Negrini S. Osteopathic Manipulative Treatment Effect on Pain Relief and Quality of Life in Oncology Geriatric Patients: A Nonrandomized Controlled Clinical Trial. Integr Cancer Ther. 2018;17(4):1163-1171. PMID: 30168356

Channell, Millicent King, Wang, Yvette, McLaughlin, Matthew H. Ciesielski, Pomerants, Sherry C. Osteopathic Manipulative Treatment for Older Patients: A National Survey of Osteopathic Physicians. J Am Osteopath Assoc. March 2016, Vol 116 e136-143. DOI: 10.7556/jaoa.2016.030. PMID: 26927907

Lopez D, King HH, Knebl JA, Kosmopoulos V, Collins D, Patterson RM: Effects of comprehensive osteopathic manipulative treatment on balance in elderly patients: a pilot study. J Am Osteopath Assoc. 2011 Jun;111(6):382-8. PMID: 21771924

Cardiovascular

Yuschak E, Haq F, Chase S. A Case of Venous Thoracic Outlet Syndrome: Primary Care Review of Physical Exam Provocative Tests and Osteopathic Manipulative Technique Considerations. Cureus. 2019;11(6):e4921. PMID: 31233114

Belash VO, Mokhov DE, Tregubova ES. [The use of the osteopathic correction for the combined treatment and rehabilitation of the patients presenting with the vertebral artery syndrome]. Vopr Kurortol Fizioter Lech Fiz Kult. 2018;95(6):34-43. PMID: 30499484

Anderson Z, Nuño V, Pierce-talsma S. An Osteopathic Approach to Stasis Dermatitis and Chronic Venous Insufficiency. J Am Osteopath Assoc. 2018;118(12):e204-e205. PMID: 30476998

Thomaz SR, Teixeira FA, De lima ACGB, Cipriano júnior G, Formiga MF, Cahalin LP. Osteopathic manual therapy in heart failure patients: A randomized clinical trial. J Bodyw Mov Ther. 2018;22(2):293-299. PMID: 29861222

Galindez-ibarbengoetxea X, Setuain I, Andersen LL, et al. Effects of Cervical High-Velocity Low-Amplitude Techniques on Range of Motion, Strength Performance, and Cardiovascular Outcomes: A Review. J Altern Complement Med. 2017;23(9):667-675. PMID: 28731832

Racca V, Bordoni B, Castiglioni P, Modica M, Ferratini M. Osteopathic Manipulative Treatment Improves Heart Surgery Outcomes: A Randomized Controlled Trial. Ann Thorac Surg. 2017;104(1):145-152. PMID: 28109570

Giles PD, Hensel KL, et al: Suboccipital decompression enhances heart rate variability indices of cardiac control in healthy subjects. J Altern Complement Med. 2013 Feb;19(2):92-6. doi: 10.1089/acm.2011.0031. Epub 2012 Sep 20. PMID: 22994907

Gastroenterology

Lagrange A, Decoux D, Briot N, et al. Visceral osteopathic manipulative treatment reduces patient reported digestive toxicities induced by adjuvant chemotherapy in breast cancer: A randomized controlled clinical study. Eur J Obstet Gynecol Reprod Biol. 2019;241:49-55.

Modlin SE, Borofka K, Franzini D, Klene-bowns AC, Nuño VA. OMT for the Prevention and Management of Chronic Constipation and Distal Intestinal Obstructive Syndrome in Cystic Fibrosis: A Pilot Study. J Am Osteopath Assoc. 2019;119(7):e31-e35.

Espí-lópez GV, Inglés M, Soliva-cazabán I, Serra-añó P. Effect of the soft-tissue techniques in the quality of life in patients with Crohn’s disease: A randomized controlled trial. Medicine (Baltimore). 2018;97(51):e13811. PMID: 30572544

Silva ACO, Biasotto-gonzalez DA, Oliveira FHM, et al. Effect of Osteopathic Visceral Manipulation on Pain, Cervical Range of Motion, and Upper Trapezius Muscle Activity in Patients with Chronic Nonspecific Neck Pain and Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Evid Based Complement Alternat Med. 2018;2018:4929271. PMID: 30534176

Shadiack E, Jouett N, Van den raadt A, et al. Osteopathic Manipulative Treatment Alters Gastric Myoelectric Activity in Healthy Subjects. J Altern Complement Med. 2018; PMID: 30376351

Aquino A, Perini M, Cosmai S, et al. Osteopathic Manipulative Treatment Limits Chronic Constipation in a Child with Pitt-Hopkins Syndrome. Case Rep Pediatr. 2017;2017:5437830. PMID: 28251008

Belvaux A, Bouchoucha M, Benamouzig R. Osteopathic management of chronic constipation in women patients. Results of a pilot study. Clin Res Hepatol Gastroenterol. 2017;41(5):602-611. PMID: 28215390

Other Areas of Research

Nuño V et al: Osteopathic Manipulative Treatment for Allostatic Load Lowering. J Am Osteopath Assoc 2019;119(10):646–654. doi: https://doi.org/10.7556/jaoa.2019.112. PMID: 31566692

Sherman T, Qureshi Y, Bach A. Osteopathic Manipulative Treatment to Manage Ophthalmic Conditions. J Am Osteopath Assoc. 2017;117(9):568-575. PMID: 28846123

Ault B, Levy D: Osteopathic Manipulative Treatment use in the Emergency Department: A retrospective Medical Record Review. J Am Osteopath Assoc. March 2015. Vol 115, 132-137. DOI: 10.7556/jaoa.2015.026. PMID: 25722359

Licciardone JC, Kearns CM, King HH, Seffinger MA, Crow WT, Zajac P, Devine WH, Abu-Sbaih RY, Miller SJ, Berkowitz MR, Dyer R, Heath DM, Treffer KD, Nevins NA, Aryal S: Somatic dysfunction and use of osteopathic manual treatment techniques during ambulatory medical care visits: a CONCORD-PBRN study. J Am Osteopath Assoc. 2014 May;114(5):344-54. doi: 10.7556/jaoa.2014.072. PMID: 24777999

Anglund DC, Channell MK: Contribution of osteopathic medicine to care of patients with chronic wounds. J Am Osteopath Assoc. 2011 Sep;111(9):538-42. PMID: 21955533

Marx S, Cimniak U, Beckert R, Schwerla F, Resch KL: [Chronic prostatitis/chronic pelvic pain syndrome. Influence of osteopathic treatment – a randomized controlled study]. Urologe A. 2009 Nov;48(11):1339-45. doi: 10.1007/s00120-009-2088-z. German. Erratum in: Urologe A. 2010 Jan;49(1):55. PMID: 19705093

Channell MK: Modified Muncie technique: osteopathic manipulation for eustachian tube dysfunction and illustrative report of case. J Am Osteopath Assoc. 2008 May;108(5):260-3. PMID: 18519836